山东省济宁市太白湖新区荷花路133号 科研楼3楼
jby2006@126.com
教育和工作经历
2021.08-至今 半岛电竞棋牌网址 教授 副院长
2013.07- 2021.07济宁医学院精神卫生学院 副教授 办公室主任
2006.07- 2013.06济宁医学院生物科学学院 讲师
2012.09- 2017.07山东农业大学 神经生物学专业 博士
2003.09- 2006.07山东师范大学 细胞生物学专业 硕士
1997.09-2001.07山东师范大学 生物科学专业 学士
研究领域与方向
主要研究G蛋白偶联受体二聚化及其信号转导机制;神经肽及其受体在阿尔茨海默病、抑郁症等神经精神疾病中的作用及其分子机制。
荣誉、奖励及主要社会兼职
2.中国神经科学学会(CNS)会员
3.中国细胞生物学学会(CSCB)会员
基金资助
1.山东省优质研究生课程:细胞生物学技术(2023.01-2025.12)
2.山东省自然科学基金面上项目:BK/B2R系统通过促进APP的非淀粉样蛋白水解抑制阿尔茨海默病Aβ生成的机制研究(2021.01-2023.12)
3.山东省教育科学“十四五”规划课题:基于脑科学的医学细胞生物学课堂教学策略研究(2022.01-2023.12)
4.山东省医药卫生科技发展计划项目:基于CREB-BDNF通路的GHSR1a-APJ异源二聚体抗抑郁症机制研究(2020.06-2022.06)
代表性论文
1.Ji Bingyuan*, Liyan Shang, Chunmei Wang, Lei Wan, Baohua Cheng, Jing Chen*. Roles for heterodimerization of APJ and B2R in promoting cell proliferation via ERK1/2-eNOS signaling pathway. Cellular Signalling, 2020, 73:109671.
2.Ji Bingyuan*,Qinqin Wang, Qingjie Xue, Wenfu Li, Xuezhi Li and Yili Wu*. The Dual Role of Kinin/Kinin receptor syetem in Alzheimer’s Disease. Frontiers in molecular neuroscience, 2019, 12: 234.
3.Ji Bingyuan,Liu H, Zhang R, Jiang Y, Wang C, Li S, Chen J, Bai B. Novel signaling of dynorphin at kappa-opioid receptor/bradykinin B2 receptor heterodimers. Cellular signalling 2017, 31:66-78.
4.Ji Bingyuan, Cheng B, Pan Y, Wang C, Chen J, Bai B. Neuroprotection of bradykinin/bradykinin B2 receptor system in cerebral ischemia. Biomedicine & pharmacotherapy, 2017, 94:1057-1063.
5. Li W, Li G,Ji Bingyuan, Zhang Q, Qiu J*. Neuroanatomical Correlates of Creativity: Evidence From Voxel-Based Morphometry. Frontiers in psychology 2019, 10:155.
6. Liu Y*, Zhang N, Bao G, Huang Y,Ji Bingyuan*, Wu Y*, Liu C, Li G. Predictors of depressive symptoms in college students: A systematic review and meta-analysis of cohort studies. Journal of affective disorders 2019, 244:196-208.
7. Kong Q, Hao Y, Li X, Wang X,Ji Bingyuan*, Wu Y*. HDAC4 in ischemic stroke: mechanisms and therapeutic potential. Clinical epigenetics 2018, 10(1):117.
8. Kong T, Liu M,Ji Bingyuan, Bai B, Cheng B, Wang C*. Role of the Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury. Front Physiol, 2019, 10:1038
9. Wang Q, Wang C,Ji Bingyuan, Zhou J, Yang C, Chen J*. Hapln2 in Neurological Diseases and Its Potential as Therapeutic Target. Frontiers in aging neuroscience 2019, 11:60.
10.Wang C, Wang Q,Ji Bingyuan, Pan Y, Xu C, Cheng B, Bai B, Chen J*. The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases. Frontiers in molecular neuroscience 2018, 11:220.
11.Liu H, Tian Y,Ji Bingyuan, Lu H, Xin Q, Jiang Y, Ding L, Zhang J, Chen J*, Bai B*. Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2-biased pathway. Biochimica et biophysica acta 2016, 1863(11):2719-2738.