The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation
发布时间:2021/09/19 03:33:57

During tumorigenesis, tumors must evolve to evade the immune system and do so by disrupting the genes involved in antigen processing and presentation or up-regulating inhibitory immune checkpoint genes. We performed in vivo CRISPR screens in syngeneic mouse tumor models to examine requirements for tumorigenesis both with and without adaptive immune selective pressure. In each tumor type tested, we found a marked enrichment for the loss of tumor suppressor genes (TSGs) in the presence of an adaptive immune system relative to immunocompromised mice. Nearly one-third of TSGs showed preferential enrichment, often in a cancer- and tissue-specific manner. These results suggest that clonal selection of recurrent mutations found in cancer is driven largely by the tumor’s requirement to avoid the adaptive immune system.


. 2021 Sep 17;373(6561):1327-1335.

doi: 10.1126/science.abg5784.


该研究发现肿瘤抑制基因的失活,在肿瘤免疫逃逸中也扮演了重要角色。

版权所有:半岛电竞棋牌网址   地址:济宁市北湖新区荷花路133号科研楼三楼  邮编:272067

Baidu
map