杨睿,博士,副教授
山东省济宁市太白湖新区荷花路133号 科研楼3楼
simply_yang@126.com
教育和工作经历
2018.09-至今 半岛电竞棋牌网址
2015.09-2018.07西南大学 家蚕基因组生物学国家重点实验室 生物化学与分子生物学博士
2012.09-2015.07西南大学 家蚕基因组生物学国家重点实验室 细胞生物学硕士
2008.09-2012.07泰山医学院 生物技术 学士
研究领域与方向
主要研究表观遗传学在肿瘤细胞代谢调控网络中的作用及分子机制。
基金资助
1.国家自然科学基金青年基金项目:HOXA3协同KMT2C/HOXA3/HK2途径调控胶质瘤细胞糖酵解促进其恶性进展的机制研究 (2021.01-2023.12)
2.山东省自然科学基金青年基金项目(2021.01-2023.12)
3.济宁医学院国家自然科学基金培育项目 (2020.01-2022.12)
4.济宁医学院博士科研启动基金(2018.09-2023.08)
代表性论文
1.Yang R*, Zhang G, Dong Z, Wang S, Li Y, Lian F, Liu X, Li H, Wei X, Cui H*. Homeobox A3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression.Neuro- Oncology. 2023, 25(4): 635-647.
2. Zhang G, Tan R, Wan S,Yang R, Hu X, Zhao E, Ding X, Zhang J, Li B, Liang P*, Cui, H*. HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.Br J Cancer. 2022, 127(11): 1925-1938.
3.Yang R*, Wang M, Zhang G, Li Y, Wang L, Cui H*. POU2F2 regulates glycolytic reprogramming and glioblastoma progression via PDPK1-dependent activation of PI3K/AKT/mTOR pathway. Cell Death Dis. 2021 Apr 30;12(5):433.
4.Yang R*, Li X, Wu Y, Zhang G, Liu X, Li Y, Bao Y, Yang W, Cui H*. EGFR activates GDH1 transcription to promote glutamine metabolism through MEK/ERK/ELK1 pathway in glioblastoma.Oncogene. 2020 Apr; 39(14): 2975-2986.
5.Yang R*, Wang M, Zhang G, Bao Y, Wu Y, Li X, Yang W, Cui H*. E2F7-EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression.Br J Cancer. 2020 Oct; 123(9): 1445-1455.
6. Dong Z, Lei Q,Yang R,Zhu S, Ke X, Yang L, Cui H*, Yi, L*. Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma.Br J Cancer. 2017 Jun 6; 116(12): 1572-1584.
7.Yang R,Yi L, Dong Z, Ouyang Q, Zhou J, Pang Y, Wu Y, Xu L*, Cui, H*. Tigecycline Inhibits Glioma Growth by Regulating miRNA-199b-5p-HES1-AKT Pathway.Mol Cancer Ther. 2016 Mar; 15(3): 421-429.
8. Ouyang Q, Chen G, Zhou J, Li L, Dong Z,Yang R,Xu L, Cui H, Xu M*, Yi L*. Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p.Neuro Oncol. 2016 Feb; 18(2): 216-226.