连福明，博士，副教授，院长助理

山东省济宁市太白湖新区荷花路133号 科研楼3楼

fmlian@mail.jnmc.edu.cn

教育和工作经历

2016.05 –至今 济宁医学院半岛彩票官网首页入口 ，硕士研究生导师

2013.05 – 2016.05香港大学李嘉诚医学院博士后研究员(Post-doctorial Fellow)

2007.09 – 2012.07中国科学技术大学生命科学学院生物化学与分子生物学博士

2003.09 – 2007.07青岛大学医学院生物技术学士

研究领域与方向

从事与疾病相关蛋白质的结构与功能研究，主要关注于参与肿瘤发生与耐药、氧化应激应答、DNA损伤应答等蛋白质的结构机制与药理学研究。主要研究方向：（1）重大疾病相关蛋白质的结构研究；（2）基于靶点结构的药物设计；（3）结构药理学研究

荣誉、奖励及主要社会兼职

1. 济宁医学院自然科学二等奖

2.济宁医学院欧美同学会（留学人员联谊会）理事

3.Journal of Biomolecular Structure & Dynamics、Anti-Cancer Agents in Medicinal Chemistry、Protein & Peptide Letters等多种SCI期刊审稿人

基金资助

1.国家自然科学基金面上项目：基于DTNB二硫键交联研究Prx5催化能力再生的分子结构机制（2022.01-2025.12）

2.国家自然科学基金青年基金项目：XPA-RPA复合物参与核苷酸切除修复通路DNA损伤确认的关键组装机制研究（2018.01-2020.12）

代表性论文

1.Lian, Fu-Ming*; Jiang, Yong-Liang; Yang, Wancai; Yang, Xiangwei*, Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 mimics a conformational intermediate during the catalytic cycle,International Journal of Biological Macromolecules, 2020, 161:1055-1060.

2.Lian, Fu-Ming*; Yang, Xiangwei; Jiang, Yong-Liang; Yang, Feng; Li, Changlin; Yang, Wancai; Qian, Chengmin*. New structural insights into the recognition of undamaged splayed-arm DNA with a single pair of non-complementary nucleotides by human nucleotide excision repair protein XPA,International Journal of Biological Macromolecules, 2020, 148:466-474.

3. Li, Changlin*; Sun, Hui; Wei, Wei; Liu, Qiuzi; Wang, Yinglei; Zhang, Ying;Lian, Fuming; Liu, Fangchao; Li, Chenchen; Ying, Kaicheng; Huo, Hang; Qi, Zhi; Li, Benyi*; Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression,Cellular Oncology,2020, 43(6):1099-1116.

4.Lian, Fu-Ming*; Yang, Xiangwei; Yang, Wancai; Jiang, Yong-Liang; Qian, Chengmin*; Structural characterization of the redefined DNA-binding domain of human XPA,Biochemical and Biophysical Research Communications, 2019, 514(3):985-990.

5.Lian, Fu-Ming*; Yang, Xiangwei; Yang, Wancai; Jiang, Yong-Liang; Qian, Chengmin*; The redefined DNA-binding domain of human xeroderma pigmentosum complementation group A: production, crystallization and structure solution,Acta Crystallographica Section F- Structural Biology Communications, 2019,75(Pt 1):62-66.

6. Li, Tao; Wang, Linsheng; Du, Yongming; Xie, Si; Yang, Xi;Lian, Fuming; Zhou, Zhongjun*; Qian, Chengmin*; Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation,Nucleic Acids Research, 2018, 46(6):3218-3231.

7.Lian, Fu-Ming; Xie, Si; Qian, Chengmin*; Crystal structure and SUMO binding of Slx1-Slx4 complex,Scientific Reports, 2016, 6:19331.

8. Mu, Yinnan#;Lian, Fu-Ming#; Teng ,Yan-Bin; Ao, Jingqun; Jiang, Yong-Liang; He, Yong-Xing; Chen, Yuxing; Zhou, Cong-Zhao*; Chen, Xinhua*; The N-terminal beta-sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaena crocea is involved in its biological functions,PLoS One, 2013, 8(2):e57061.

9.Lian, Fu-Ming; Yu, Jiang; Ma, Xiao-Xiao; Yu, Xiao-Jie; Chen, Yuxing; Zhou, Cong-Zhao*; Structural snapshots of yeast alkyl hydroperoxide reductase Ahp1 peroxiredoxin reveal a novel two-cysteine mechanism of electron transfer to eliminate reactive oxygen species,Journal of Biological Chemistry, 2012, 287(21):17077-17087.