This article provides a status report on theglobalburden ofcancerworldwide using the GLOBOCAN 2018 estimates ofcancerincidence and mortality produced by the International Agency for Research onCancer, with a focus on geographic variability across 20 world regions. There will be an estimated 18.1 million newcancercases (17.0 million excluding nonmelanoma skincancer) and 9.6 millioncancerdeaths (9.5 million excluding nonmelanoma skincancer) in 2018. In both sexes combined, lungcanceris the most commonly diagnosedcancer(11.6% of the total cases) and the leading cause ofcancerdeath (18.4% of the totalcancerdeaths), closely followed by female breastcancer(11.6%), prostatecancer(7.1%), and colorectalcancer(6.1%) for incidence and colorectalcancer(9.2%), stomachcancer(8.2%), and livercancer(8.2%) for mortality. Lungcanceris the most frequentcancerand the leading cause ofcancerdeath among males, followed by prostate and colorectalcancer(for incidence) and liver and stomachcancer(for mortality). Among females, breastcanceris the most commonly diagnosedcancerand the leading cause ofcancerdeath, followed by colorectal and lungcancer(for incidence), and vice versa (for mortality); cervicalcancerranks fourth for both incidence and mortality. The most frequently diagnosedcancerand the leading cause ofcancerdeath, however, substantially vary across countries and within each country depending on the degree of economic development and associated social and life style factors. It is noteworthy that high-qualitycancerregistry data, the basis for planning and implementing evidence-basedcancercontrol programs, are not available in most low- and middle-income countries. TheGlobalInitiative forCancerRegistry Development is an international partnership that supports better estimation, as well as the collection and use of local data, to prioritize and evaluate nationalcancercontrol efforts. CA: ACancerJournal for Clinicians 2018;0:1-31.

美国神刊CA （IF=245）最新发布的全球癌症发病率及死亡率的统计，供大家阅读及引用！